Resistant Cancer Cell Line Collection

Jindrich Cinatl
Dr Petra Joh-Forschungshaus
Frankfurter Stiftung für krebskranke Kinder
Frankfurt am Main, Germany

Wass-Michaelis Research Group
School of Biosciences
University of Kent
Kent, UK
Investigate Data for a single Drug: vincristine
Vincristine - Drug Information
Basic information about the drug is displayed below. This has been extracted from the Wikipedia entry for the drug - https://en.wikipedia.org/wiki/Vincristine
Drug Structure
Vincristine.svg
Vincristine3DanBS.gif
Clinical data
Trade names Oncovin, Vincasar, others
AHFS/Drugs.com Monograph
MedlinePlus a682822
Pregnancy
category
US: D (Evidence of risk)
Routes of
administration
Intravenous
ATC code L01CA02 (WHO)
Pharmacokinetic data
Bioavailability n/a (not reliably absorbed by the GI tract)
Protein binding ~44%
Biological half-life 19 to 155 hours (mean: 85 hours)
Excretion Faeces (70-80%), urine (10-20%)
Identifiers
Synonyms cisplatinum, platamin, neoplatin, cismaplat, cis-diamminedichloridoplatinum(II) (CDDP)
CAS Number 57-22-7
PubChem CID 5978
DrugBank DB00541
ChemSpider 5758
KEGG D08679
ChEBI CHEBI:28445
ChEMBL CHEMBL303560
Vincristine Drug sensitivity Data
The table and barchart show all drug sensitivity data for vincristine

In the bar chart resistant sub-lines are shown in a lighter shade of the parental cell line