Wass-Michaelis Research Group

School of Biosciences
University of Kent
Kent, UK



Changes associated with Ebola virus adaptation to novel species
Pappalardo M et al., Wass MN, Bioinformatics - In press
Acquired resistance to oxaliplatin is not directly associated with increased resistance to DNA damage in SK-N-ASrOXALI4000, a newly established oxaliplatin-resistant sub-line of the neuroblastoma cell line SK-N-AS
Saintas E et al., Wass MN, Michaelis M, PLOS One 12 e0172140
Effects of YM155 on survivin levels and viability in neuroblastoma cells with acquired drug resistance
Voges Y, Michaelis M, et al., Wass MN, Rodel F, Cinatl J., Cell Death and Disease 7, e2410
Risks Posed by Reston, the Forgotten Ebolavirus
D Cantoni, A Hamlet, M Michaelis, MN Wass, JS Rossman, mSphere 1 (6), e00322-16
An expanded evaluation of protein function prediction methods shows an improvement in accuracy
Jiang et al., Genome Biology 2016
Computational analysis of Ebolavirus data: prospects, promises and challenges
Michaelis M, Rossman JS, Wass MN Biochem Soc Trans (2016) 44:973-978
Desulfovibrio vulgaris CbiKP cobaltochelatase: Evolution of a haem binding protein orchestrated by the incorporation of two histidine residues
Susana A.L. Lobo, Marco A.M. Videira, Isabel Pacheco, Mark N. Wass, Martin J. Warren, Miguel Teixeira, Pedro M. Matias, Celia V. Romao, Ligia M. Saraiva
Conserved differences in protein sequence determine the human pathogenicity of Ebolaviruses
Pappalardo M, Julia M, Howard M, Rossman JS, Michaelis M, Wass MN
Substrate-specific effects of pirinixic acid derivatives on ABCB1-mediated drug transport
Michaelis M, Rothweiler F, Wurglics M, Aniceto N, Dittrich M, Zettl H, Wiese M, Wass M, Ghafourian T, Schubert-Zsilavecz M, Cinatl J.(2016) Oncotarget,In press doi: 10.18632/oncotarget.7345
The Role of Protein Modelling in Predicting the Disease Severity of Cystinuria
Wong KA, Wass M, Thomas K (2015) European Urology, 69, 543-4.
The Phyre2 web portal for protein modeling, prediction and analysis
Kelley LA, Mezulis S1, Yates CM, Wass MN , Sternberg MJ.(2015) Nature Protocols, 10, 845-58
Ten simple rules for a community computational challenge
Friedberg I, Wass MN, Mooney SD, Radivojac P., Thomas K (2015) PLOS Comp Bio, 11, e1004150.
Identification of flubendazole as potential anti-neuroblastoma compound in a large cell line screen
Michaelis M, Agha B, Rothweiler F, Löschmann N, Voges Y, Mittelbronn M, Starzetz T, Harter PN, Abhari BA, Fulda S, Westermann F, Riecken K, Spek S, Langer K, Wiese M, Dirks WG, Zehner R, Cinatl J, Wass MN , Cinatl J Jr.(2015) Sci Rep, 5, 8202
Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility
Talman AM, Prieto JH, Marques S, Ubaida-Mohien C, Lawniczak M, Wass MN, Xu T, Frank R, Ecker A, Stanway RS, Krishna S, Sternberg MJ, Christophides GK, Graham DR, Dinglasan RR, Yates JR 3rd, Sinden RE. (2015) Malar J. 2014, 13, 315.
The South Asian genome
Chambers JC, Abbott J, Zhang W, Turro E, Scott WR, Tan ST, Afzal U, Afaq S, Loh M, Lehne B, O'Reilly P, Gaulton KJ, Pearson RD, Li X, Lavery A, Vandrovcova J, Wass MN , Miller K, Sehmi J, Oozageer L, Kooner IK, Al-Hussaini A, Mills R, Grewal J, Panoulas V, Lewin AM, Northwood K, Wander GS, Geoghegan F, Li Y, Wang J, Aitman TJ, McCarthy MI, Scott J, Butcher S, Elliott P, Kooner JS (2014) PLOS One, 9, e102645
The genetic diversity of cystinuria in a UK population of patients
Wong KA, Mein R, Wass M, Flinter F, Pardy C, Bultitude M, Thomas K (2015) BJU Int, 116, 109-16.
VarMod: modelling the functional effects of non-synonymous variants
Pappalardo M, Wass MN (2014) Nucl Acids Res, 42, W331-6
The automated function prediction SIG looks back at 2013 and prepares for 2014
Wass MN, Mooney SD, Linial M, Radivojac P, Friedberg I (2014) Bioinformatics, 30, 2091-2.
A large-scale evaluation of computational protein function prediction.
Radivojac et al., (2013) Nature Methods,10, 221-227
CombFunc: predicting protein function using heterogeneous data sources
Wass M.N., Barton G., Sternberg M.J. et al., (2012) Nucleic Acids Research,40, W466-470.
Proteomic analysis of Plasmodium in the mosquito: progress and pitfalls. Journal of Parasitology
Wass M.N., Stanway, R., Blagborough, A., Lal, K., Prieto, J.H., Raine, D., Sternberg, M.J.,
Talman, A.M., Tomley F., Yates III, J., Sinden, R.E. (2012) Parasitology, 139, 1131-1145.
Protein-protein interaction sites are hot spots for disease-associated non-synonymous SNPs
David, A., Razali, R., Wass, M.N.*, Sternberg, M.J.E.* (2011) . Human Mutation,33, 359–363.
*Joint senior author
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
Chambers JC, Zhang W, Sehmi J, Li X, Wass M.N.* et al., (2011) Nat Genet. doi: 10.1038/ng.970
*Co first author
Challenges for the prediction of macromolecular interactions
Wass M.N
., David A., Sternberg M.J. (2011) . Curr Op Struct Biol. 21:382-90
Towards the prediction of interaction partners using Physical docking
Wass M.N., Fuentes G., Pons, C., Pazos F., Valencia A. (2011) . Mol Syst Biol 7:469
The flagellum in malarial parasites
Sinden R.E., Talman A., Marques S.R., Wass M.N., Sternberg M.J. (2010). Curr Opin Microbiol. 13:491-500
3DLigandSite: predicting ligand-binding sites using similar structures
Wass M.N
, Kelley L.A. and Sternberg M.J. (2010). NAR 38, W469-73
Genetic loci influencing kidney function and chronic kidney disease
Chambers J.C. et al., (2010) . Nat Genet 42:373-5
Genetic variation in SCN10A influences cardiac conduction
Chambers, J.C. et al., (2010) Nat Genet, 42:149-52
Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels
Chambers, J.C., Zhang, W., Li, Y., Sehmi, J., Wass, M.N. et al., (2009) . Nat Genet, 41, 1170-2.
Prediction of ligand binding sites using homologous structures and conservation at CASP8
Wass, M.N.
and Sternberg, M.J. (2009). Proteins, 77 Suppl 9:147-51.

ConFunc--functional annotation in the twilight zone
Wass, M.N
. and Sternberg, M.J. (2008) Bioinformatics, 24, 798-806.

Convergent Evolution of Enzyme Active Sites Is not a Rare Phenomenon
Gherardini, P.F., Wass, M.N., Helmer-Citterich, M. and Sternberg, M.J. (2007). J Mol Biol, 372, 817-845.

Mitochondrial proton leak in metabolic depression:Life in Limbo.
Brand, M. D., Boutilier, R. G., Wass, M., St-Pierre, J. & Bishop, T. (2001). In Molecular Mechanisms of Metabolic Arrest edited by K. B. Storey, 59-76